Established / Validated
HRT Use Linked to Lower Dementia Risk in Specific Postmenopausal Subgroups
A large-scale study of over 183,000 postmenopausal women found that hormone replacement therapy (HRT) use for at least one year is associated with a 10% lower risk of all-cause dementia. The protective association was most pronounced among women who underwent surgical menopause, carried the APOE ε4 gene, or initiated therapy between ages 46 and 56.
alz-journals.onlinelibrary.wiley.com
Last reviewed Aug 30, 2026
